Abstract
IT is now well established that homologous disease follows the injection of immunologically competent cells into new-born animals1–3, F1 hybrids4,5, irradiated animals6 and adult animals rendered tolerant by neonatal injections of lymphoid cells7, as well as after repeated injection of a large number of lymphoid cells into adults8. Peripheral blood lymphocytes have been shown to be immunologically competent, and homologous disease has been produced by the injection of whole blood9, or buffy-coat layer cells10. To reduce the amount of damage suffered by lymphocytes during manipulation in vitro, a technique has been developed for cross-circulating the blood between two rats. Using this technique, homologous disease has been produced with the parent–F1 hybrid combination, and the problem of whether transfused parental strain lymphocytes continue to recirculate in the host after transfusion, or whether they are rapidly fixed in the tissues, has been investigated.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Billingham, R. E., and Brent, L., Transplant. Bull., 4, 67 (1957).
Simonsen, M., Acta Path. and Microbiol. Scand., 4, 480 (1957).
Woodruff, M. F. A., and Sparrow, M., Transplant. Bull., 4, 147 (1957).
Cock, A. G., and Simonsen, M., Immunology, 1, 103 (1958).
Trentin, J. J., Fed. Proc., 17, 461 (1958).
Trentin, J. J., Ann. N.Y. Acad. Sci., 73, 799 (1958).
Martinez, C., Smith, J. M., and Good, R. A., Proc. Soc. Exp. Biol. and Med., 106, 572 (1961).
Shapiro, F., Martinez, C., Smith, J. M., and Good, R. A., Proc. Soc. Exp. Biol. and Med., 106, 472 (1961).
Cole, L. J., and Garver, R. M., Amer. J. Physiol., 200, 147 (1961).
Billingham, R. E., and Silvers, W. K., J. Immunol., 83, 667 (1959).
Belcher, E. H., and Harris, E. B., J. Physiol., 139, 64 (1957).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CAUCHI, M. Fixation of Parental Strain Lymphocytes in F1 Hybrid Rats during Cross-circulation. Nature 209, 817–818 (1966). https://doi.org/10.1038/209817a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/209817a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
