Abstract
TRENTIN et al.1 demonstrated that hamsters inoculated at birth with adenovirus 12 develop a high incidence of malignant tumours, and that viral multiplication does not seem to occur under these conditions. On the other hand, adenovirus 5 is apparently not oncogenic for hamsters2, but it has been reported to induce a lethal infection in new-born animals including lesions of liver cells similar to those observed in cultured human epithelial cells in which the virus is multiplying3. Further investigations4 have recently shown that the pathogenicity of adenovirus 5 for new-born hamsters depends on the virus doses inoculated, no pathological symptoms being observed below 108 T.C.I.D. 50.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Trentin, J. J., Yabe, Y., and Taylor, G., Science, 137, 835 (1962).
Girardi, A. J., Larson, V. M., and Hilleman, M. R., Proc. Soc. Exp. Biol. and Med., 118, 173 (1964).
Pereira, H. G., Allison, A. C., and Niven, J. S., Nature, 196, 244 (1942).
Samaille, J., Vivier, E., Dubois, D., and Petitprez, A., C.R. Acad. Sci. Paris, 260, 1030 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PERIES, J., CHUAT, J., CANIVET, M. et al. Inhibition of Adenovirus 12 Oncogenicity in Hamsters by Simultaneous Inoculation with Adenovirus 5. Nature 209, 738–739 (1966). https://doi.org/10.1038/209738a0
Issue Date:
DOI: https://doi.org/10.1038/209738a0
This article is cited by
-
Studies on inhibition of viral oncogenesis
Archiv f�r die gesamte Virusforschung (1972)
-
Inhibition of Tumour Formation with Adenovirus 12 Tumour Cells in Hamsters immunized with Various Adenoviruses
Nature (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
