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A New Method of detecting Homograft Sensitivity

Abstract

IN the course of studying the distribution of chromium-51-labelled lymph node cells injected intravenously or intraperitoneally into A-strain mice1, it was found that the uptake of allogeneic and syngeneic cells differed in certain organs. This suggested that it might also be possible to detect differences of uptake between the tissues of control animals and of mice which had previously been sensitized to the donor strain antigens.

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References

  1. Bainbridge, D. R., Brent, L., and Gowland, G., Transplantation (in the press).

  2. Billingham, R. E., and Brent, L., Phil. Trans. Roy. Soc., B, 242, 439 (1959).

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  3. Scalfe, J. F., and Vittorio, P. V., Canad. J. Biochem., 42, 503 (1964).

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  4. Billingham, R. E., Brent, L., Brown, J. B., and Medawar, P. B., Transplant. Bull., 6, 410 (1959).

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BAINBRIDGE, D., GOWLAND, G. A New Method of detecting Homograft Sensitivity. Nature 209, 624–625 (1966). https://doi.org/10.1038/209624a0

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