Abstract
Mandel, Cambosos and Smith1 have reported that appreciable amounts of acetylsalicylic acid can be present in human plasma and that it may be detected for up to 2 h after its oral administration. Also, from the work of Davison and Smith2, the plasma proteins may bind acetylsalicylic acid to a much smaller extent than salicylic acid, thus making a greater proportion available for excretion. It should, therefore, be expected that some acetylsalicylic acid will be excreted in the urine.
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References
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CUMMINGS, A., KING, M. Urinary Excretion of Acetylsalicylic Acid in Man. Nature 209, 620–621 (1966). https://doi.org/10.1038/209620a0
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DOI: https://doi.org/10.1038/209620a0
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