Abstract
IT is well established that phlorrhizin and its aglycone phloretin affect hexose transfer in a number of tissues. Recently Forsling and Widdas1 showed that phenolphthalein caused competitive inhibition of facilitated glucose transfer in human erythrocytes. In view of its purgative action, it was of interest to test whether phenolphthalein also affected intestinal transfer mechanisms. At the same time the opportunity was taken to test another poly-phenolic compound phenol red (phenolsulphonphthalein), a molecule of similar structure which is known to be transferred by the renal tubule. The formulae of these compounds are shown in Fig. 1.
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References
Forsling, M. L., and Widdas, W. F., J. Physiol., 178, 12P (1965).
Barry, B. A., Matthews, J., and Smyth, D. H., J. Physiol., 157, 279 (1961).
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Jervis, E. L., Johnson, F. B., Sheff, M. F., and Smyth, D. H., J. Physiol., 134, 675 (1956).
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HAND, D., SANFORD, P. & SMYTH, D. Polyphenolic Compounds and Intestinal Transfer. Nature 209, 618 (1966). https://doi.org/10.1038/209618a0
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DOI: https://doi.org/10.1038/209618a0
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