Abstract
INTESTINAL absorption of radio-iron in intact rats was increased during the enhanced erythropoiesis which followed haemolysis induced by phenylhydrazine1. Similarly, erythropoiesis stimulated by acetylphenylhydrazine in dogs also increased iron absorption in vivo2. This report describes experiments designed to study the effects of increased erythropoiesis in the rat on iron transport across everted duodenal gut sacs in vitro. The in vitro technique has defined an active transport mechanism for iron absorption3,4 which varies adaptively with dietary iron and pregnancy5 and, as will be shown, the cellular mechanism is also involved in the response to increased erythropoiesis.
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MANIS, J., SCHACHTER, D. Active Transport of Iron by Intestine : Effect of Erythropoiesis stimulated by Phenylhydrazine. Nature 209, 1356 (1966). https://doi.org/10.1038/2091356a0
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DOI: https://doi.org/10.1038/2091356a0
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