Abstract
THE wide distribution of natural anti-tumour agents has been shown by Szent-Györgyi et al.1 and many others. There is, notably, such a compound in human urine, which has been called retine and has been previously isolated by Hegyeli et al.2. This compound has a molecular weight of approximately 430 (ref. 3) and induces a significant regression of Krebs-2 carcinoma in Swiss albino mice. Treatment of retine with hot acetic acid releases a compound which is responsible for the anti-tumour activity4.
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References
Szent-Györgyi, A., Hegyeli, A., and McLaughlin, J., Proc. U.S. Nat. Acad. Sci., 49, 878 (1963).
Hegyeli, A., McLaughlin, J., and Szent-Györgyi, A., Science, 142, 1571 (1963).
Marmasse, C., Hegyeli, A., and King, A. (to be published).
Hegyeli, A. (personal communication).
Jaffe, H., and Orchin, M., Theory and Application of Ultraviolet Spectroscopy (Wiley, New York, 1962).
Karrer, P., Organic Chemistry, fifth English ed. (Elsevier, Amsterdam, 1950).
Dashkevich, L., and Sirraya, V., Zh. Obshch. Khim., 32, 2330 (1962). (See Chem. Abs., 58, 7946; 1963.)
Krepelka, J., and Vebersik, V., Chem. Listy, 43, 25 (1949). (See Chem. Abs., 44, 9565; 1950.)
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MARMASSE, C. Chemical Nature of Free Retine, an Anti-tumour Agent. Nature 209, 1346–1347 (1966). https://doi.org/10.1038/2091346b0
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DOI: https://doi.org/10.1038/2091346b0
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