Abstract
Cameron and Staveley1 found that the echinococcus cyst fluid contains P blood group substance if there are scolices present in the cysts. When the echinococcus cyst fluid is used as an antigen, excellent anti-P1 sera are produced in goats2. In rabbits the production of P1 antibodies can also be stimulated, but not by application of the cyst fluid alone3. We have explored another source of antigen, Lumbricus terrestris4. Sodium chloride extracts, both cooked and uncooked, contain a fairly large amount of P1 substance together with H substance and B blood group substance. Some of the extracts inhibited also anti-A, but never anti-M, anti-N, or anti-D. The long-lasting immunity of man against Ascaris gave rise to the idea that the P1 cold antibodies which are ‘genuinely’ present in the sera of P2 group people could have developed following antigenic stimulation by Ascaris lumbricoides or other nemathelminthes. We therefore studied sodium chloride extracts from Ascaris suum and observed a high content of substance inhibiting anti-P1 sera as well as A and H substances. By means of sodium chloride extracts from Lumbricus, P2 erythrocytes pretreated with tannin can be transformed into P1 erythrocytes. The extract can be cooked and we have been using it for the immunization of goats. The detailed quantitative relations will be referred to elsewhere.
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References
Cameron, G. L., and Staveley, J. M., Nature, 179, 147 (1957).
Kerde, Ch., et al., Ztschr. f. Immun. Forsch., 119, 216 (1960).
Prokop, O., and Oesterle, P., Blut, 4, 157 (1958).
Prokop, O., and Schlesinger, D., Acta Biol. German., 15, 1 (1965).
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PROKOP, O., SCHLESINGER, D. P1 Blood Group Substance in Lumbricus terrestris (Earthworm) and Ascaris suum. Nature 209, 1255 (1966). https://doi.org/10.1038/2091255a0
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DOI: https://doi.org/10.1038/2091255a0
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