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Synthesis of α2-AP (Acute Phase) Globulin of Rat Serum by the Liver

Nature volume 209, pages 1032–1033 (1966)Cite this article

Abstract

THE appearance of a new protein in rat serum in a wide variety of pathological and physiological states has been reported by several investigators in recent years1,2. The protein which we have designated α2-AP (acute phase) globulin1 has also been referred to as slow α2-globulin (SA2G) (ref. 1), abnormal serum component1, reproduction-associated protein1, and α2-glycoprotein (α2-GP) (ref. 2). The presence of the protein in serum has been detected by immunological procedures1,2 and by filter paper-1 and starch-gel-electrophoretic analyses1. The present communication reports the demonstration of the synthesis of α2-AP globulin by the liver during the acute phase of an inflammatory response.

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References

  1. Weimer, H. E., and Benjamin, D. C., Amer. J. Physiol., 209, 736 (1965).

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  2. Bogden, A. E., Rosenkrantz, H., and Gray, J. H., Fed. Proc., 24, 230 (1965).

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  3. Weimer, H. E., Benjamin, D. C., and Darcy, D. A., Nature, 208, 1221 (1965).

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Authors and Affiliations

  1. Department of Medical Microbiology and Immunology, Center for the Health Sciences, University of California, Los Angeles

    D. C. BENJAMIN & H. E. WEIMER

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  1. D. C. BENJAMIN
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  2. H. E. WEIMER
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BENJAMIN, D., WEIMER, H. Synthesis of α2-AP (Acute Phase) Globulin of Rat Serum by the Liver. Nature 209, 1032–1033 (1966). https://doi.org/10.1038/2091032b0

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