Intracellular Distribution of the Different Forms of Lactic Dehydrogenase

Abstract

THERE is, at present, considerable interest in the investigation of the properties and metabolic roles of the five molecular forms of lactic dehydrogenase (LDH). A preponderance of forms I and II was found in tissues (for example, heart) which function under relatively aerobic conditions, whereas a preponderance of forms IV and V was observed in relatively anaerobic tissues (muscle, liver)^1,2. In a conference on lactic acids recently held in New York, however, it was brought out in discussion that the intracellular distribution of the different forms of LDH had not then been investigated³.