Abstract
THE insecticide ‘Isolan’ (1-isopropyl-3-methyl-5-pyrazolyl dimethylcarbamate) is more toxic to rats by the dermal than by the oral route1. This finding is interesting, because the opposite is true of most compounds. It was not known whether the unexpected difference in the toxicity of ‘Isolan’ by the two routes was caused by detoxification in the intestinal lumen, poor absorption from the gastrointestinal tract, detoxification in the liver, unusually efficient percutaneous absorption, or some other mechanism.
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References
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GAINES, T., HAYES, W. & LINDER, R. Liver Metabolism of Anticholinesterase Compounds in Live Rats : Relation to Toxicity. Nature 209, 88–89 (1966). https://doi.org/10.1038/209088a0
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DOI: https://doi.org/10.1038/209088a0
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