Abstract
THE clear-cut demonstration by Piez1 that the 3 α-chains of cod-fish skin tropocollagen are unique, and the likelihood that a similar condition is true for all species of tropocollagen, have led me to consider various simple arrays of sub-units within the chains which could explain their known compositional features. I have arrived at a model in which an α-chain consists of 6 sub-units, each of approximately 17,000 molecular weight, and falling into 3 different compositional types that I call A, B and C, respectively. A tropocollagen unit, then, in this model would consist of a total of 18 sub-units: 6A, 6B, 6C. Of all the possible combinations of 6 sub-units of 3 types in an α-chain, one which fits the known analyses of the amino-acid compositions of the several types of α-chains in the various tropocollagens is the following: α1 = 3A + 2B + C; α2 = 3C + 2A + B; α3 = 3B + 2C + A For purposes of reference we designate this particular model as the 3,2,1 : A,B,C model, indicating that each different α-chain in the tropocollagen unit consists of a different array of the sub-units, but similar in that it has 3 of one kind of sub-unit, 2 of a second, and 1 of the third.
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References
Piez, K. A., J. Biol. Chem., 239, PC4315 (1964).
Blumenfeld, O. O., and Gallop, P. M., Biochemistry, 1, 947 (1962).
Blumenfeld, O. O., Paz, M., Gallop, P. M., and Seifter, S., J. Biol. Chem., 238, 3835 (1963).
Piez, K. A., Eigner, E., and Lewis, M., Biochemistry, 2, 58 (1963).
Blumenfeld, O. O., Rojkind, M., and Gallop, P. M., Fed. Proc., 24, 358 (1965).
Blumenfeld, O. O., Rojkind, M., and Gallop, P. M., Biochemistry, 4, 1780 (1965).
Petruska, J. A., and Hodge, A. J., Proc. U.S. Nat. Acad. Sci., 51, 871 (1964).
Bornstein, P., and Piez, K. A., J. Clin. Invest., 43, 1813 (1964).
Lewis, M., and Piez, K. A., J. Biol. Chem., 239, 3336 (1964).
Hörmann, H., Joseph, K. T., and von Wilm, Hoppe-Seylers Zeitschrift f. Physiol. Chemie, 341, 284 (1965).
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GALLOP, P. 3,2,1: A,B,C Sub-unit Hypothesis for the α-Chains of Tropocollagen. Nature 209, 73–74 (1966). https://doi.org/10.1038/209073a0
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DOI: https://doi.org/10.1038/209073a0
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