Abstract
THE H-viruses are a new group of small agents, 180–250 Å in diameter, distinguished by their ability to produce a ‘mongoloid-type’ deformity in new-born hamsters1,2 and, in the case of H-1 to cross the placenta and cause malformation of the hamster embryo3–5. These viruses have been isolated from two host sources, man and rat. Two members of the group, H-1 and H-3, which differ from one another serologically, were first isolated from human tumours transplanted in conditioned animals; afterwards they, as well as HT and HB, were obtained directly from human embryos, placentas, and neoplasms6. Recently it was demonstrated that two human subjects injected with H-1 virus developed haemagglutination-inhibiting (HA-I) and neutralizing antibodies to H-1 (ref. 7). This indication that man is susceptible to infection by H-1 virus is supported by the observation that HA-I and neutralizing antibodies to H-1 virus have been found in the sera of several cancer patients, laboratory personnel, and pregnant women6,8. It has also been learned that rhesus monkeys are susceptible to infection with H-1 (ref. 9).
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References
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TOOLAN, H., LEDINKO, N. Growth and Cytopathogenicity of H-viruses in Human and Simian Cell Cultures. Nature 208, 812–813 (1965). https://doi.org/10.1038/208812a0
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DOI: https://doi.org/10.1038/208812a0
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