Abstract
THERE is now considerable evidence that halogenated derivatives of the nucleoside 2′-deoxyuridine inhibit the growth of viruses that have DNA as their nucleic acid constituent but not of those containing RNA1,2. Inhibition occurs at a stage of nucleotide assembly and the thymidine analogue 5-iodo-2′-deoxyuridine (IUdR) has been shown to be incorporated into the DNA of vaccinia virus3. For cells infected with herpes simplex, this inhibition is partly reversible when thymidine is added together with the drug4.
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Salzman, N. P., Virology, 10, 150 (1960).
Herman, E. C., jun., Proc. Soc. Exp. Biol. and Med., 107, 142 (1961).
Prusoff, W. H., Bakhle, Y. S., and McCrea, J. F., Nature, 199, 1310 (1963).
Roizman, B., Aurelian, L., and Roane, P. R., jun., Virology, 21, 482 (1963).
Watrach, A. M., Vatter, A. E., Hanson, L. E., Watrach, M. A., and Rhoades, H. E., Amer. J. Vet. Res., 20, 537 (1959).
Fitzgerald, J. E., and Hanson, L. E., Amer. J. Vet. Res., 24, 103, 1297 (1963).
Howes, D. W., Tannock, G. A., and Sinkovic, B., Proc. Twelfth World's Poultry Congress, Sydney, Sect. Papers, 344 (1962).
Rubin, H., Virology, 10, 29 (1960).
Buthala, D. A., Proc. Soc. Exp. Biol. and Med., 115, 69 (1964).
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TANNOCK, G. Nucleic Acid of Infectious Laryngotracheitis Virus. Nature 208, 711–712 (1965). https://doi.org/10.1038/208711a0
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DOI: https://doi.org/10.1038/208711a0
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