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Cholinergic Excitation and Inhibition in the Cerebellar Cortex

Abstract

THE cholinergic character of mossy fibres and especially that of their endings in the parenchyma islets of the cerebellum has been repeatedly demonstrated both biochemically1 and histochemically2–6. There is also evidence for the cholinergic nature of Golgi axons, synapsing with granule cell dendrites in the cerebellar glomeruli7, although it appears that at this site an adrenergic mechanism is involved as well. The experiments reported here were performed on the cerebella of guinea-pigs; they suggest that cholinergic mechanisms are involved both in the parallel axon-Purkinje dendritic spine synapses (regarded as excitatory junctions8) and in the basket axon-Purkinje cell-body synapses (supposed to be inhibitory in their character8.)

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References

  1. Hebb, K., Int. Rev. Neurobiol., 1, 163 (1959).

    Google Scholar 

  2. Koelle, G. B., J. Comp. Neurol., 100, 211 (1954).

    Article  CAS  Google Scholar 

  3. Gerebtzoff, M. A., Cholinesterases (Pergamon Press, New York, 1959).

    Google Scholar 

  4. Tewari, H. B., and Bourne, G. H., Acta Anat., 51, 349 (1962).

    Article  CAS  Google Scholar 

  5. Csillik, B., Joó, F., and Kása, P., J. Histochem. Cytochem., 11, 113 (1963).

    Article  CAS  Google Scholar 

  6. Kása, P., Joó, F., and Csillik, B., J. Neurochemistry, 12, 31 (1965).

    Article  Google Scholar 

  7. Kása, P., and Csillik, B., Second Intern. Cong. Histochem. Cytochem. (Frankfurt am Main, 1964).

    Google Scholar 

  8. Eccles, J. C., The Physiology of Synapses (Academic Press, New York, 1964).

    Book  Google Scholar 

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KÁSA, P., CSILLIK, B. Cholinergic Excitation and Inhibition in the Cerebellar Cortex. Nature 208, 695–696 (1965). https://doi.org/10.1038/208695a0

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