Abstract
AN abnormal marker chromosome in chronic granulo-cytic leukaemia was described by No well and Hunger ford1,2 and its occurrence widely confirmed3–7. This marker, the Philadelphia chromosome (Ph1), occurs in almost all typical cases of chronic granulocytic leukaemia and appears to be an acquired abnormality specific for the disease. The Ph1 is derived from a chromosome of pair 21 by loss of a variable proportion of the long arms.
Similar content being viewed by others
Article PDF
References
Nowell, P. C., and Hungerford, D. A., J. Nat. Cancer Inst., 25, 85 (1960).
Nowell, P. C., and Hungerford, D. A., Science, 132, 1497 (1960).
Baikie, A. G., Court Brown, W. M., Buckton, K. E., Harnden, D. G., Jacobs, P. A., and Tough, I. M., Nature, 188, 1165 (1960).
Tough, I. M., Court Brown, W. M., Baikie, A. G., Buckton, K. E., Harnden, D. G., Jacobs, P. A., King, M. J., and McBride, J. A., Lancet, i, 411 (1961).
Kinlough, M. A., and Robson, H. N., Brit. Med. J., ii, 1052 (1961).
Adams, A., Fitzgerald, P. H., and Gunz, F. W., Brit. Med. J., ii, 1474 (1961).
Fitzgerald, P. H., Adams, A., and Gunz, F. W., Blood, 21, 183 (1963).
Tough, I. M., Jacobs, P. A., Court Brown, W. M., Baikie, A. G., and Williamson, E. R. D., Lancet, i, 844 (1963).
Baikie, A. G., Lancet, i, 556 (1964).
MacKinney, A. A., Stohlman, F., and Brecher, G., Blood, 19, 349 (1962).
Whang, J., Frei, E., Tjio, J. H., Carbone, P. P., and Brecher, G., Blood, 22, 664 (1963).
Spiers, A. S. D., and Baikie, A. G. (in preparation).
Baker, M. C., and Atkin, N. B., Lancet, i, 1164 (1963).
Nowell, P. C., Exp. Cell Res., 19, 267 (1961).
Tough, I. M., Court Brown, W. M., Baikie, A. G., Buckton, K. E., Harnden, D. G., Jacobs, P. A., and Williams, J. A., Lancet, ii, 115 (1962).
Sandberg, A. A., Ishihara, T., Crosswhite, L. H., and Hauschka, T. S., Cancer Res., 22, 748 (1962).
Dougan, L., and Woodliff, H. J., Nature, 205, 405 (1965).
Kemp, N. H., Stafford, J. L., and Tanner, R., Brit. Med. J., i, 1010 (1964).
Hammouda, F., Quaglino, D., and Hayhoe, F. G. J., Brit. Med. J., i, 1275 (1964).
Spiers, A. S. D., and Baikie, A. G. (in preparation).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SPIERS, A., BAIKIE, A. Chronic Granulocytic Leukaemia: Demonstration of the Philadelphia Chromosome in Cultures of Spleen Cells. Nature 208, 497 (1965). https://doi.org/10.1038/208497a0
Issue Date:
DOI: https://doi.org/10.1038/208497a0
This article is cited by
-
Aspetti citogenetici della leucemia mieloide cronica
La Ricerca in Clinica e in Laboratorio (1973)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.