Abstract
BLOOD contains a proenzyme, plasminogen (profibrinolysin), which is converted to the proteolytic enzyme plasmin (fibrinolysin) by plasminogen activator. The level of plasminogen activator in the blood is increased in conditions of stress and after injection of epinephrine or nicotinic acid1,2. The origin of blood plasminogen activator has not been established with certainty although it has been suggested that it may be derived from the plasminogen activator activity found in association with the endothelial lining of vessel walls3–5. In dogs, blood fibrinolytic activity can be increased by intravenous injection of a number of vasoactive drugs6,7, but vasodilative drugs (for example, histamine) appear to be more effective than vasoconstrictive ones8.
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References
Sherry, S., Fletcher, A. P., and Alkajaersig, N., Physiol. Rev., 39, 343 (1959).
Fletcher, A. P., Biederman, O., Moore, D., Alkjaersig, N., and Sherry, S., J. Clin. Invest., 43, 681 (1964).
Warren, B. A., Brit. Med. Bull., 20, 213 (1964).
Messer, D. L., Celander, D. R., and Guest, M. M., Circ. Res., 11, 832 (1962).
Chakrabarti, R., Birks, P. M., and Fearnley, G. R., Lancet, i, 1288 (1963).
Holemans, R., Med. Exper., 9, 5 (1963).
Holemans, R., and Langdell, R. D., Proc. Soc. Exp. Biol. and Med., 115, 584 (1964).
Holemans, R., Amer. J. Physiol., 208, 511 (1965).
Astrup, T., and Mullertz, S., Arch. Biochem. Biophys., 40, 346 (1952).
Lassen, M., Acta Physiol. Scand., 27, 371 (1953).
Holemans, R., J. App. Physiol., 18, 1123 (1963).
Todd, A. S., J. Path. Bact., 78, 281 (1959).
Owren, P. A., Acta Med. Scand., Supp. 194, 125 (1947).
Trueta, J., Barclay, A. E., Daniel, P. M., Franklin, K. J., and Prichard, M. M. L., Studies on the Renal Circulation (Blackwell Scientific Publications, Oxford, 1947).
Holemans, R., and Johnston, J. G. (unpublished observations).
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HOLEMANS, R., JOHNSTON, J. & REDDICK, R. Release of Plasminogen Activator by the Isolated Perfused Dog Kidney. Nature 208, 291–292 (1965). https://doi.org/10.1038/208291a0
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DOI: https://doi.org/10.1038/208291a0
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