Abstract
THIS communication reports the first bisalbuminaemic family found in France. As the family tree shows (Fig. 1), the anomaly seems to be due to a co-dominant, autosomal allele at the albumin locus; we have confirmed this general conclusion. The separation of the two albumins was excellent on a cellulose acetate strip (Fig. 2) and shows, without any doubt, that the anomalous albumin is the slower one. But free electrophoresis using a Perkin–Elmer apparatus disclosed only a weak ‘shoulder’ on the cathodic side of the albumin band (Fig. 3). Immunoelectrophoresis and the Ouchterlony test using anti-human serum, or specific anti-human albumin serum, did not show any difference between the two albumins (Fig. 4). The anomalous albumin, evaluated after dye elution on the cellulose acetate strip, represents in all cases about 40 per cent of the total albumin. The subjects presenting the anomalous trait were normal in all other respects.
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References
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SANDOR, G., MARTIN, L., PORSIN, M. et al. A New Bisalbuminaemic Family. Nature 208, 1222 (1965). https://doi.org/10.1038/2081222a0
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DOI: https://doi.org/10.1038/2081222a0
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