Abstract
SEVERAL substances have been described as causing reversal of the adrenergic vasodepression observed after blockade of α-receptors, adrenaline reacquiring its usual pressor action. However, when tested in animals treated with long-acting, potent and almost irreversible adrenergic blocking drugs like the β-haloalkylamines dibenamine and phenoxybenzamine, only some pressor agents as, for example, ephedrine, vasopressin, methoxamine, phenylephrine and barium chloride1–3 provoke with regularity negation of adrenergic blockade. In an attempt to investigate the mechanism of this anti-adrenolytic action further, we used the β-adrenergic blocking drug, pronethalol (‘Nethalide’, ‘Alderlin’, ref. 4) and made the unexpected finding that it also causes restoration of the pressor action of adrenaline, when injected after blockade of α-receptors.
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References
Levy, B., and Ahlquist, R. P., J. Pharmacol. Exper. Therap., 121, 414 (1957).
Osswald, W., Inversao Vasomotora (thesis, Porto, 1958).
Osswald, W., Arch. Intern. Pharmacodyn., 126, 346 (1960).
Black, J. W., and Stephenson, J. S., Lancet, ii, 311 (1962).
Karim, S., Brit. J. Pharmacol., 23, 594 (1964).
Sutherland, J. H. R., Ahlquist, R. P., and Ogden, W. S., Fed. Proc., 23, 124 (1964).
Levy, B., J. Pharmacol Exper. Therap., 146, 129 (1964).
Butterworth, K. R., Brit. J. Pharmacol., 21, 378 (1963).
Koch-Weser, E., J. Pharmacol Exper. Therap., 146, 318 (1964).
Nickerson, M., Henry, J. W., and Nomaguchi, G. M., J. Pharmacol. Exper. Therap., 107, 300 (1953).
Osswald, W., and Guimarães, S., Nauyn-Schmiedeberg's Arch. exp. Path, u. Pharmak., 243, 1 (1962).
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MOREIRA, M., OSSWALD, W. Pronethalol-induced Reversal of Adrenergic Vasodepression. Nature 208, 1006–1007 (1965). https://doi.org/10.1038/2081006a0
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DOI: https://doi.org/10.1038/2081006a0
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Orientierende Übersicht
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