Letter | Published:

Iodine-125-labelled L Chains of Human Blood Group Antibodies

Naturevolume 207pages989990 (1965) | Download Citation



Cohen and Porter1 have demonstrated that the light (L) chains of human IgG globulins can be separated into ten subtractions by starch-gel electrophoresis. They also showed that the L chains of guinea-pig anti-ovalbumin and anti-(bovine serum albumin) separated into ten subfractions, but the intensity of the staining of the bands differed from each other and from those of L chains obtained from IgG globulins. The work presented here is concerned with the distribution of 125I-labelled L chains of human antibody among the ten subtractions.

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  1. 1

    Cohen, S., and Porter, R. R., Biochem. J., 90, 278 (1964).

  2. 2

    Fleischman, J. B., Pain, R. H., and Porter, R. R., Arch. Biochem. Biophys. Suppl. No. 1, 174 (1962).

  3. 3

    Hughes-Jones, N. C., Gardner, B., and Telford, R., Immunology, 7, 72 (1964).

  4. 4

    Cohn, E. J., and Edsall, J. T., Proteins, Amino-acids and Peptides, 85 (Reinhold Publishing Corporation, 1943).

  5. 5

    Hughes-Jones, N. C., Gardner, B., and Telford, R., Biochem. J., 88, 435 (1963).

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  1. Wright-Fleming Institute of Microbiology, St. Mary's Hospital Medical School, London, W.2.



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