Letter | Published:

Chemical Structure and Biological Activity on m-and p-Disubstituted Derivatives of Benzene

Naturevolume 207page981 (1965) | Download Citation

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Abstract

IN an earlier paper on this topic1 we proposed a four-parameter equation (1), which expresses the quantitative relationship between the structure of p-disubstituted derivatives of benzene and the magnitude of their biological activity, for example intravenous LD50. This report presents our results on a group of compounds of the type NO2, NH2. The series includes all possible combinations of groups X and Y, with the exception of three substances which were not soluble enough even in 20 per cent aqueous polyvinylpyrrolidone solution to make LD50 measurements possible. The experimental results fitted equation

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References

  1. 1

    Boček, K., Kopecký, J., Krivucová, M., and Vlachová, D., Experientia, 20, 667 (1964).

  2. 2

    Hammett, L. P., Physical Organic Chemistry (McGraw-Hill, New York, 1940).

  3. 3

    Taft, jun., R. W., J. Amer. Chem. Soc., 75, 4231 (1953).

  4. 4

    Zahradník, R., Experientia, 18, 534 (1962).

  5. 5

    Zahradník, R., Arch. Int. Pharmacodyn., 135, 311 (1962).

  6. 6

    Hansch, C., Maloney, P. P., Fujita, T., and Muir, R. M., Nature, 194, 178 (1962).

  7. 7

    Hansch, C., Muir, R. M., Fujita, T., Maloney, P. P., Geiger, F., and Streich, M., J. Amer. Chem. Soc., 85, 2817 (1963).

  8. 8

    Hansch, C., and Fujita, T., J. Amer. Chem. Soc., 86, 1616 (1964).

  9. 9

    Bruice, T. C., Kharasch, N., and Winzler, R. J., Arch. Biochem. Biophys., 62, 305 (1956).

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Affiliations

  1. Institute of Industrial Hygiene and Occupational Diseases, Prague, Czechoslovakia

    • J. KOPECKÝ
    • , K. BOČEK
    •  & D. VLACHOVÁ

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https://doi.org/10.1038/207981a0

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