Letter | Published:

Kinetics of Cyclic Adenosine Monophosphate Changes in Rat Heart following Epinephrine Administration

Naturevolume 207pages979981 (1965) | Download Citation



ALTHOUGH it has become generally accepted1 that epinephrine causes glycogenolysis in cardiac muscle by a series of enzymatic reactions involving the formation of cyclic AMP, activation of phosphorylase b kinase, and finally conversion of phosphorylase b to the active a form, direct evidence in favour of this mechanism in the intact heart is so far not conclusive2. Furthermore, a possible relation between cyclic AMP and the inotropic effect of catecholamines is also tentative.

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  1. JOHN R. WILLIAMSON: Recipient of a Wellcome travel scholarship.


  1. Johnson Research Foundation, University of Pennsylvania, Philadelphia



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