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Functional Homology of the Sex-Factor and Resistance Transfer Factors

Naturevolume 207pages884885 (1965) | Download Citation

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Abstract

DRUG-BESISTANT bacteria can emerge from sensitive populations by acquiring a ‘resistance factor’ (R-factor)1,2 from another strain by conjugation. Genetically, an R-factor behaves as an extrachromosomal structure2 belonging to the same class of elements as the transmissible sex-factor (F)3,4 of Escherichia coli, and its derivatives (designated F′) in which a fragment of bacterial chromosome has become associated with F (ref. 5). In an R-factor a collection of genes determining resistance to one or as many as six different drugs is transferred as a single unit of inheritance linked to a resistance transfer factor (RTF) responsible for the transmission2.

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References

  1. 1

    Watanabe, T., and Fukasawa, T., J. Bact., 81, 669 (1961).

  2. 2

    Watanabe, T., Bact. Rev., 27, 87 (1963).

  3. 3

    Hayes, W., J. Gen. Microbiol., 8, 72 (1953).

  4. 4

    Lederberg, J., Cavalli, L. L., and Lederberg, E. M., Genetics., 37, 720 (1952).

  5. 5

    Jacob, F., and Adelberg, E. A., C. R. Acad. Sci., Paris, 249, 189 (1959).

  6. 6

    Ørskov, I., and Ørskov, F., Acta Path. Microbiol. Scand., 48, 37 (1960).

  7. 7

    Loeb, T., and Zinder, N. D., Proc. U.S. Nat. Acad. Sci., 47, 282 (1961).

  8. 8

    Brinton, C. C., Gemski, P., and Carnahan, J., Proc. U.S. Nat. Acad. Sci., 52, 776 (1964).

  9. 9

    Sugino, Y., and Hirota, Y., J. Bact., 84, 902 (1962).

  10. 10

    Hirota, Y., Nishimura, Y., Ørskov, F., and Ørskov, I., J. Bact., 87, 341 (1964).

  11. 11

    Watanabe, T., Fukasawa, T., and Takano, T., Virology, 17, 218 (1962).

  12. 12

    Watanabe, T., Nishida, H., Ogata, C., Arai, T., and Sato, S., J. Bact., 88, 716 (1964).

  13. 13

    Watanabe, T., and Fukasawa, T., J. Bact., 83, 727 (1962).

  14. 14

    Watanabe, T., J. Bact., 85, 788 (1963).

  15. 15

    Katznelson, H., and Sutton, M. D., J. Bact., 61, 689 (1951).

  16. 16

    Cooper, S., and Zinder, N. D., Virology, 18, 405 (1962).

  17. 17

    Dettori, R., Maccacaro, G. A., and Turri, M., Giorn. Microbiol., 11, 15 (1963).

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Affiliations

  1. Medical Research Council Microbial Genetics Research Unit, Hammersmith Hospital

    • ELINOR MEYNELL
    •  & NAOMI DATTA
  2. Department of Bacteriology, Postgraduate Medical School, London

    • ELINOR MEYNELL
    •  & NAOMI DATTA

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https://doi.org/10.1038/207884a0

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