Letter | Published:

Incidence and Lobar Distribution of Bronchiectasis in a Colony of Wistar Albino Rats

Naturevolume 207pages659660 (1965) | Download Citation



IN some recent dietary investigations using a closed colony of Wistar albino rats the most common pathological condition was an inflammatory and suppurative disease of the lungs. This disease, a form of bronchiectasis, occurs frequently as a natural disease in rats, both domesticated and wild1, and has previously been described2. In extent it varies from a small focus of inflammation in one lobe of the lung to the entire lung being shrunken and nodular, the tissue of each lobe being converted into large sacs consisting of distended bronchi filled with a compacted caseous mass. Nelson and Gowen1 have reported the incidence of the disease in male and female rats but only from a total of 145 animals. Other reports give the percentage incidence for the entire colony regardless of age and sex2,3. In the work recorded here 1,238 rats were examined and as no dietary differences were found4 the opportunity was taken to sum over diet to obtain a detailed picture of the incidence of this natural disease in the colony. Particulars of the maintenance of the colony are given by Hickman et al.5.

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  1. 1

    Nelson, J. B., and Gowen, J. W., J. Infect. Dis., 46, 53 (1930).

  2. 2

    Passey, R. D., Leese, A., and Knox, J. C., J. Path. and Bact., 42, 425 (1936).

  3. 3

    Cruickshank, A. H., J. Path and Bact., 60, 520 (1948).

  4. 4

    Greenwood, T., and Jefferies, D. J., AERE Res. Rep., R.4344 (1963).

  5. 5

    Hickman, J. R., McLean, D. L. A., Law, A. W., and Bostock, C. J. M., AERE Res. Rep. R.4016 (1962).

  6. 6

    Nelson, J. B., J. Exp. Med., 84, 7 (1946).

  7. 7

    Nelson, J. B., J. Exp. Med., 84, 15 (1946).

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  1. Isotope Research Division, U.K. Atomic Energy Authority Research Group, Wantage Research Laboratory, Berks

    •  & D. J. JEFFERIES


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