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Migration of Spleen Cells into the Blood Stream following Antigen Stimulation of the Rat

Naturevolume 207pages654655 (1965) | Download Citation



A MARKED cellular hyperplasia occurs in the rat spleen in response to a single intravenous injection of a particulate antigen1–3. This hyperplasia is predominantly manifested in the red pulp, which exhibits a striking increase in the number of actively mitotic, large pyroninophilic cells within 2 days after antigen administration. The proliferation of these cells, which have been shown to be intimately associated with antibody formation in the rat4,5 as well as in other species6, reaches a maximum on about the fourth day after antigen. Later, their number rapidly diminishes so that by the ninth day the spleen has largely regained its pre-stimulation pattern and few if any of these cells appear to differentiate locally into plasma cells.

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  1. Department of Pathology and the Argonne Cancer Research Hospital (Operated by the University of Chicago for the U.S. Atomic Energy Commission), University of Chicago, Illinois



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