Letter | Published:

Migration of Spleen Cells into the Blood Stream following Antigen Stimulation of the Rat

Naturevolume 207pages654655 (1965) | Download Citation

Subjects

Abstract

A MARKED cellular hyperplasia occurs in the rat spleen in response to a single intravenous injection of a particulate antigen1–3. This hyperplasia is predominantly manifested in the red pulp, which exhibits a striking increase in the number of actively mitotic, large pyroninophilic cells within 2 days after antigen administration. The proliferation of these cells, which have been shown to be intimately associated with antibody formation in the rat4,5 as well as in other species6, reaches a maximum on about the fourth day after antigen. Later, their number rapidly diminishes so that by the ninth day the spleen has largely regained its pre-stimulation pattern and few if any of these cells appear to differentiate locally into plasma cells.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Fitch, F. W., Barker, P., Soules, K. H., and Wissler, R. W., J. Lab. Clin. Med., 42, 598 (1953).

  2. 2

    Gunderson, C. H., Juras, D., LaVia, M. F., and Wissler, R. W., J. Amer. Med. Assoc., 180, 1038 (1962).

  3. 3

    Wissler, R. W., Fitch, F. W., LaVia, M. F., and Gunderson, C. H., J. Cell. Comp. Physiol., Supp. 1, 50, 265 (1957). (a) Wissler, R. W., Fitch, F. W., and LaVia, M. F., Ann. N.Y. Acad. Sci., 88, 134 (1960).

  4. 4

    Fitch, F. W., Wissler, R. W., LaVia, M., and Barker, P., J. Immunol., 76, 151 (1956).

  5. 5

    Wissler, R. W., Frazier, L. F., Soules, K. H., Barker, P., and Bristow, E. C., Amer. Med. Assoc. Arch. Path., 62, 62 (1956).

  6. 6

    Coons, A. H., Leduc, E. H., and Connolly, J. M., J. Exp. Med., 102, 49 (1955).

  7. 7

    Langevoort, H. L., Lab. Invest., 12, 106 (1963).

  8. 8

    Wissler, R. W., Robson, M. J., Fitch, F., Nelson, W., and Jacobson, L. O., J. Immunol., 70, 379 (1953).

  9. 9

    Pelc, S. R., Intern. J. Appl. Rad., 1, 172 (1956).

  10. 10

    Nossal, G. J. V., and Mäkelä, O., Lab. Invest., 10, 1094 (1961).

  11. 11

    Schooley, J. C., Bryant, B. J., and Kelly, L. S., in The Kinetics of Cellular Proliferation, edit. by Stohlman, jun., F., 208 (Grune and Stratton, Inc., New York, 1959).

Download references

Author information

Affiliations

  1. Department of Pathology and the Argonne Cancer Research Hospital (Operated by the University of Chicago for the U.S. Atomic Energy Commission), University of Chicago, Illinois

    • DONALD C. CANNON
    •  & ROBERT W. WISSLER

Authors

  1. Search for DONALD C. CANNON in:

  2. Search for ROBERT W. WISSLER in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/207654a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.