Letter | Published:

Beneficial Effect of Oxytetracycline in Cortisone-induced Wasting Disease

Naturevolume 207pages651652 (1965) | Download Citation



INJECTION of hydrocortisone into new-born mice results in the development of a wasting syndrome similar to that seen in mice after neonatal thymectomy1. McIntire et al.2 suggested that the wasting disease seen in neonatally thymectomized mice is associated with an infectious process as the wasting syndrome does not appear in neonatally thymectomized germ-free mice. Administration of antibiotics to neonatally thymectomized rats has been shown to influence favourably the subsequent development of wasting disease in these animals3,4.

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  1. 1

    Schlesinger, M., and Mark, R., Science, 143, 965 (1964).

  2. 2

    McIntire, K. R., Sell, S., and Miller, J. F. A. P., Nature, 204, 151 (1964).

  3. 3

    Azar, H. A., Proc. Soc. Exp. Biol. and Med., 116, 817 (1964).

  4. 4

    Azar, H. A., Williams, J., and Takatsuki, K., The Thymus; Wistar Inst Mon. No. 2, 75 (1964).

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    Bullough, W. S., Biol. Rev., 27, 133 (1952).

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    Lahtiharju, A., Rësänen, T., and Teir, H., Growth, 28, 221 (1964).

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  1. Cancer Research Institute, New England Deaconess Hospital, Boston, Massachusetts



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