Letter | Published:

Behaviour of Intracerebral Autografts of Mouse Tail Skin pre-treated with a Single Application of 20-Methylcholanthrene

Naturevolume 207pages649650 (1965) | Download Citation

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Abstract

THIERSCH grafts of tail skin from 30 mice of various strains and both sexes were implanted intracerebrally in an attempt to produce an expanding, space-occupying, intracranial lesion, and to investigate its effect on the surrounding brain, with particular reference to ‘cerebral oedema’. The autografts, which were cut with a Castroviejo keratome set to a thickness of 0.2 mm, measured approximately 3 mm × 1 mm. Immediately after removal they were inserted into the right cerebral hemisphere with a blunt probe, through a small hole made over the lateral aspect of the skull with a dental burr. All operative procedures were performed under ‘Nembutal’ anaesthesia.

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References

  1. 1

    Spencer, A. T., Ann. Rep. Brit. Emp. Cancer Campaign, 46, 404 (1962).

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  1. Department of Pathology, Medical School, University of Birmingham

    • A. T. SPENCER
    •  & W. THOMAS SMITH

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https://doi.org/10.1038/207649a0

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