Letter | Published:

Behaviour of Intracerebral Autografts of Mouse Tail Skin pre-treated with a Single Application of 20-Methylcholanthrene

Naturevolume 207pages649650 (1965) | Download Citation



THIERSCH grafts of tail skin from 30 mice of various strains and both sexes were implanted intracerebrally in an attempt to produce an expanding, space-occupying, intracranial lesion, and to investigate its effect on the surrounding brain, with particular reference to ‘cerebral oedema’. The autografts, which were cut with a Castroviejo keratome set to a thickness of 0.2 mm, measured approximately 3 mm × 1 mm. Immediately after removal they were inserted into the right cerebral hemisphere with a blunt probe, through a small hole made over the lateral aspect of the skull with a dental burr. All operative procedures were performed under ‘Nembutal’ anaesthesia.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Spencer, A. T., Ann. Rep. Brit. Emp. Cancer Campaign, 46, 404 (1962).

Download references

Author information


  1. Department of Pathology, Medical School, University of Birmingham

    • A. T. SPENCER
    •  & W. THOMAS SMITH


  1. Search for A. T. SPENCER in:

  2. Search for W. THOMAS SMITH in:

About this article

Publication history

Issue Date




By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.