Abstract
IT was reported recently1 that incubation of ELD ascites cells or its sublines in a tissue culture medium supplemented with cysteamine causes an increase of the cellular content of the acid-soluble, non-protein-bound sulphydryl groups (NPSH). The increase was found to be directly related to the cysteamine concentration in the medium. Expressed in SIF*, the extent of NPSH increase was similar to the extent of the increased radio-resistance expressed in DRF† of human kidney cells or mouse fibroblasts treated with cysteamine at comparable concentrations2. This similarity of SIF and DRF has been interpreted1 as indicating that the mechanism of radioprotection by cysteamine is, in some way, dependent on the increased concentration of NPSH in the protected cell. The nature of this NPSH is not known at present.
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RÉVÉSZ, L., MODIG, H. Cysteamine-induced Increase of Cellular Glutathione-level : A New Hypothesis of the Radioprotective Mechanism. Nature 207, 430–431 (1965). https://doi.org/10.1038/207430a0
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DOI: https://doi.org/10.1038/207430a0
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