Electron Microscopic Observations of Human Chromosomes isolated by Micrurgy

Abstract

THE elucidation of the structure of the human chromosome is of basic biological importance. A more detailed understanding of the mechanisms involved in utilization, duplication, and transferral of genetic information requires a concept of the physical manner in which this information exists during these three processes. To this end a number of models of chromosome structure have been proposed. These models have been based largely on light microscopic observations and electron micrographs of fragments of chromosomes of various plants and animals^1,2. So far, none of these models has been universally accepted as being representative of the human chromosome.