Phenolic and Indole Amines in the Urine of Schizophrenics


THE hypothesis that schizophrenia may be caused by a metabolic abnormality of phenolic or indolic amines has gained supporting experimental results by some research groups, but conflicting results by others. This confused state was reviewed by Kety1, and the contradictory results could be explained by various factors related to different environmental and physical conditions which are secondary to the psychosis. An attempt was made to examine in this laboratory the excretion of various phenolic and indole amines using the subjects under careful control of environmental factors.

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TAKESADA, M., MIYAMOTO, E., KAKIMOTO, Y. et al. Phenolic and Indole Amines in the Urine of Schizophrenics. Nature 207, 1199–1200 (1965).

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