Letter | Published:

Effect of Actinomycin D on the Infectivity of Trypanosoma cruzi

Naturevolume 207pages10041005 (1965) | Download Citation

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Abstract

PARTIAL immunity against a virulent and lethal strain of T. cruzi has been obtained in mice by several procedures1–4. All these procedures lead to a limited protection and are characterized by the appearance of parasites in the blood. The use of killed flagellates induces little or no resistance against the virulent strain1,5, suggesting that a mild host infection is an indispensable prerequisite for the development of even partial immunity.

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References

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    Hauschka, T. S., Goodwin, M. B., Palmquist, J., and Brown, E., Amer. J. Trop. Med., 30, 1 (1950).

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    Collier, W. A., Z. Hyg. InfektKrankh., 112, 88 (1931).

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    Browning, C. H., Calver, K. M., Leckie, M. W., and Walls, L. P., Nature, 157, 263 (1946).

  4. 4

    Pizzi, T., and Prager, R., Bol. Inform. Parasit. Chilenas, 7, 20 (1952).

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    Muniz, J., Nobrega, G., and Cunha, M., Mem. Inst. Oswaldo Cruz, 44, 529 (1946).

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    Johnson, P., Neal, R. A., and Gall, D., Nature, 200, 83 (1963).

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Affiliations

  1. Laboratory of Cellular Physiology, Faculty of Medicine, University of São Paulo, Brazil

    • J. F. FERNANDES
    • , MINA HALSMAN
    •  & OLGA CASTELLANI

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https://doi.org/10.1038/2071004a0

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