Abstract
6β-Hydroxy-3,5-cycloandrostan-17-one is related to the naturally occurring steroid dehydroepiandrosterone in that it can be readily converted to dehydroepiandrosterone under acidic conditions and can be produced by hydrolysis of solutions of dehydroepiandrosterone sulphate at elevated temperatures at neutral pH1. In addition it has been suggested that the 3,5-cyclosteroids have an ‘anti-fatigue’ effect2. For these reasons it seemed of interest to examine the metabolism of this steroid.
Similar content being viewed by others
Article PDF
References
Lieberman, S., Mond, B., and Smyles, E., Recent Prog. Hormone Res., 9, 113 (1954).
Hardwick, S. W., Pearse, J. S., and Petrow, V., J. Ment. Sci., 103, 835 (1957).
Brooks, R. V., Biochem. J., 68, 50 (1958).
Butenandt, A., and Suranyi, L. O., Ber. Deutsch. Chem. Ges., 75, 591 (1942).
Breuer, H., Vitam. and Horm., 20, 285 (1962).
Hagopian, H., Pincus, G., Carlo, J., and Romanoff, E. B., Endocrinology, 58, 287 (1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DAVIDSON, D., FOTHERBY, K. Metabolism of 6β-Hydroxy-3,5-cycloandrostan-17-one by Rabbit Liver in vitro. Nature 206, 933 (1965). https://doi.org/10.1038/206933a0
Issue Date:
DOI: https://doi.org/10.1038/206933a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.