Acetylcholine Sensitivity of Cerebellar Neurones

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Abstract

A PRELIMINARY communication from, this laboratory reported that feline Purkinje cells were excited by electrophoretically administered acetylcholine and carbaminocholine1. On the assumption that the presence of acetylcholinesterase in particular nerve fibres is indicative of their cholinergic nature2, and on the basis of the distribution of this enzyme in the cerebellum of the guinea-pig3, it was proposed that the sensitivity of Purkinje cells to cholinomimetics may be related to a transmitter function for acetylcholine at the parallel fibre—Purkinje cell dendrite synapses of the cat.

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CURTIS, D., CRAWFORD, J. Acetylcholine Sensitivity of Cerebellar Neurones. Nature 206, 516–517 (1965) doi:10.1038/206516a0

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