Acetylcholine Sensitivity of Cerebellar Neurones

Article metrics


A PRELIMINARY communication from, this laboratory reported that feline Purkinje cells were excited by electrophoretically administered acetylcholine and carbaminocholine1. On the assumption that the presence of acetylcholinesterase in particular nerve fibres is indicative of their cholinergic nature2, and on the basis of the distribution of this enzyme in the cerebellum of the guinea-pig3, it was proposed that the sensitivity of Purkinje cells to cholinomimetics may be related to a transmitter function for acetylcholine at the parallel fibre—Purkinje cell dendrite synapses of the cat.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Crawford, J. M., Curtis, D. R., Voorhoeve, P. E., and Wilson, V. J., Nature, 200, 579 (1963).

  2. 2

    Shute, C. C. D., and Lewis, P. R., Nature, 199, 1160 (1963).

  3. 3

    Gerebtzoff, M. A., Cholinesterases (Pergamon Press, 1959).

  4. 4

    Friede, R. L., and Fleming, L. M., J. Neurochem., 11, 1 (1964). Austin, L., Phillis, J. W., and Steele, R. P., Experientia, 20, 218 (1964). Kasa, P., Jóo, F., and Csillik, B., J. Neurochem. (in the press).

  5. 5

    Shute, C. C. D., and Lewis, P. R., J. Anat., 98, 466 (1964); Nature, 205, 242 (1965).

  6. 6

    Szentagothai, J., in Information Processing in the Nervous System, edit. by Gerard, R. W., and Duyff, J. W. (Excerpta Medica Found., 1964).

  7. 7

    McCance, I., and Phillis, J. W., Experientia, 20, 217 (1964). McCance, I., and Phillis, J. W., Nature, 204, 844 (1964). Phillis, J. W., Brit. Med. Bull., 21, 26 (1965).

  8. 8

    Eccles, J. C., Llinas, R., and Sasaki, K., Nature, 203, 245 (1964).

  9. 9

    Crossland, J., and Mitchell, J. F., J. Physiol., 132, 391 (1956). Crossland, J., Garvin, J. D., and Mitchell, J. F., J. Physiol., 148, 20P (1959). Crossland, J., Woodruff, G. N., and Mitchell, J. F., Nature, 203, 1388 (1964).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

CURTIS, D., CRAWFORD, J. Acetylcholine Sensitivity of Cerebellar Neurones. Nature 206, 516–517 (1965) doi:10.1038/206516a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.