Abstract
DISAPPEARANCE rates of enzymes after injection into experimental animals have so far only been measured by sequential determination of serum enzyme activity. The very short half-life of the enzymes after their entrance into the blood, in comparison with ordinary plasma proteins, has lent support to the assumption that enzymes might undergo some inactivation process during their presence in the bloodstream. Schapira et al.1, however, failed to see any inactivation of aldolase in the blood using an iodine-131 technique.
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References
Schapira, F., Dreyfus, J. C., and Schapira, G., Extrait Rev. Franç. Etud. Clin. Biol., 7, 829 (1962).
Lang, N., and Massarrat, S., Verh. Deutsch. Ges. inn. Med., 68, 275 (1962).
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Report of the Commission on Enzymes, I.U.B. Symposium Series, 20 (Pergamon Press, London, 1961).
Massarrat, S., and Lang, L., Klin. Wschr. (in the press).
Francis, G. E., Mulligan, W., and Wormall, A., Nature, 167, 748 (1951).
Fleisher, G. A., and Wakim, K. G., J. Lab. Clin. Med., 61, 76 (1963).
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MASSARRAT, S. Enzyme Kinetics, Half-life, and Immunological Properties of Iodine-131-labelled Transaminases in Pig Blood. Nature 206, 508–509 (1965). https://doi.org/10.1038/206508a0
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DOI: https://doi.org/10.1038/206508a0
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