Abstract
IT was recently reported that the bronchial muscle might have both β- and α-adrenergic receptors and that the former caused bronchodilation1. Furthermore, Takagi and Osada2 suggested that the β-receptor, and not only the α-receptor, has to be on the tracheal muscle. This suggested that the β-receptor might exert an inhibitory action on the vas deferens. Isopropylarterenol and epinephrine have the β-action and their mode of action on the vas deferens isolated from the guinea-pig (400–450 g body-weight) was investigated, using the 30 ml. organ bath at the bath temperature of 26° C. All the concentration-action curves given in this report were drawn with the cumulative technique developed at Prof. Ariens's laboratory3. All the results were presented as the mean of at least ten experiments.
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References
de la Mata, R. C., et al., J. Pharmacol. Exp. Therap., 135, 197 (1962).
Takagi, K., and Osada, E. (in preparation).
van Rossum, J. M., Arch. int. Pharmacodyn., 143, 299 (1963).
Takagi, K., and Takayanagi, I., Jap. J. Pharmacol., 14, 458 (1964) (in English).
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TAKAGI, K., TAKAYANAGI, I. β-Adrenergic Receptor on the Vas Deferens of the Guinea-pig. Nature 206, 308–309 (1965). https://doi.org/10.1038/206308a0
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DOI: https://doi.org/10.1038/206308a0
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