Abstract
RECENT investigations have revealed1 that the ratio of total histones to DNA is not significantly different within either the repressed or active chromatin fractions isolated from interphase calf thymus lymphocytes2. In addition, the relative proportions of each of the distinct types of histones are similar within both forms of chromatin1. These results confirm a similar constancy of the types and quantities of histones found previously within animal cells varying widely in their tissue of origin3, age4, rate of RNA synthesis4, or neoplastic character5,6. Although histones are potent repressors of the template function of DNA in vitro7,8, this constancy of histone type and quantity suggests that they are a necessary, but not sufficient, mechanism for effecting the differential rates of RNA synthesis observed within the nuclei of these animal cells2,9.
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FRENSTER, J. A Model of Specific De-repression within Inter phase Chromatin. Nature 206, 1269–1270 (1965). https://doi.org/10.1038/2061269a0
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DOI: https://doi.org/10.1038/2061269a0
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