A Mechanism to Limit Platelet Aggregation in vivo


INTRAVASCULAR injection of adenosine diphosphate (ADP) in several species including man1 and rabbit2 induces platelet clumping with concomitant fall in circulating platelet count. It is well established that following vascular injury white thrombi form at the site of insult3. The first stage in white thrombus formation is the adhesion of platelets to the endothelium followed by the development of a platelet aggregate by the cohesion of discrete platelets. The forces binding the aggregate appear strong; but, if the thrombus is not stabilized by the deposition of fibrin, then a process of platelet dispersal commences. Platelets which have dispersed from aggregates have been shown to retain their propensity for ADP-induced cohesion.

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RUTTY, D. A Mechanism to Limit Platelet Aggregation in vivo. Nature 206, 1263–1264 (1965). https://doi.org/10.1038/2061263a0

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