Abstract
TREMORINE (1-4 dipyrolidine-2-butyn (T)) has stimulated an interest in an experimental pharmacology because it is the first substance which can definitely produce rest tremor, rigor and akinesia, that is, the symptoms of Parkinson's disease1. Further, the symptoms produced in tremorine-induced tremor (TT) can be relieved with all known, anti-Parkinson substances and drugs inhibiting the cholinergic nervous system. Recently, Cho and Jendon2 found that symptoms produced with (T) or with oxotremorin (oxo-T), an active principle of T, can be removed with an analogue of T, 1-4-bis(N-hexamethylenimino)-2-butyn (anti-T). T itself is the most specific substance. Everett1 states that among many similar derivatives only T produces tremor.
Similar content being viewed by others
Article PDF
References
Everett, G., Nature, 177, 1238 (1956).
Cho, A. K., and Jenden, D. J., Intern. J. Neuropharmacol., 3, 27 (1964).
Zetler, G., Arch. Intern. Exp. Path., 228, 513 (1956).
Herz, A., Arch. Exp. Path. Pharmacol., 241, 176 (1961).
Ahmed, A., Marschall, P. B., and Shepherd, D. M., J. Pharmacy and Pharmacol., 10, 672 (1958).
Ahmed, A., and Taylor, N. R. W., Brit. J. Pharmacol., 14, 350 (1959).
Stern, P., Ratković, D., and Fuks, Ž., Arch. Intern. Pharmacodyn., 130, 1 (1961).
Stern, P., and Gašparović, I., Proc. First. Intern. Pharmacol. Meeting, 8, 149 (1962).
Ratković, D., Stern, P., and Bošković, B., Bull. Sci. (in the press).
Bull, G., Hebb, C., and Ratković, D., Biochim. Biophys. Acta, 67, 138 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
STERN, P., RADOVIĆ, N. & BULJUBAŠIĆ, S. Pharmacology of Experimental Tremor. Nature 206, 1261 (1965). https://doi.org/10.1038/2061261a0
Issue Date:
DOI: https://doi.org/10.1038/2061261a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.