Transport of Sodium and Water by Rabbit Ileum, in vitro and in vivo


PREVIOUS studies from this laboratory1,2 have indicated a deficiency of Na+ ion absorption from the gastrointestinal tract in cholera1, and an inhibition of Na+ transport in the short-circuited frog skin in the presence of cholera stool. We are studying animal models to elucidate intestinal mucosal cell function in cholera. A difference in function has been noted when Na+ ion transfer in the everted intestinal sac in vitro was compared with data from loops of the adult rabbit in vivo.

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  1. 1

    Phillips, R. A., Blackwell, R. Q., Wallace, C. K., and Huber, G. S., Fed. Proc., 22 (1963).

  2. 2

    Huber, G. S., and Phillips, R. A., SEATO Conference on Cholera, Dacca, East Pakistan, 37 (National Institutes of Health, 1962).

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LOVE, A., MITCHELL, T. & NEPTUNE, E. Transport of Sodium and Water by Rabbit Ileum, in vitro and in vivo. Nature 206, 1158 (1965).

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