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Extraction of Aflatoxin from Rat Liver

Nature volume 206, pages 1045–1046 (1965)Cite this article

Abstract

It has been shown that a single dose of aflatoxin B1 given to a rat will result in acute liver damage1. Histologically the lesion, which is periportal in distribution, develops slowly as compared with either carbon tetrachloride2 or dimethylnitrosamine (DMN)3. Necrosis is first seen at 36–48 h. The liver parenchyma regenerates slowly and is accompanied by a biliary proliferation. After one month the liver still shows the biliary proliferation and also large hyperchromatic parenchymal cells.

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References

  1. Butler, W. H., Brit. J. Cancer, 18, 756 (1964).

    Article  CAS  Google Scholar 

  2. Cameron, G. R., and Karunaratne, W. A. E., J. Path. Bact., 42, 1 (1936).

    Article  CAS  Google Scholar 

  3. Barnes, J. M., and Magee, P. N., Brit. J. Indust. Med., 11, 167 (1954).

    CAS  Google Scholar 

  4. de lough, H., van Pelt, J. G., Ord, W. O., and Barrett, C. B., Vet. Rec., 76, 901 (1964).

    Google Scholar 

  5. Allcroft, R., and Carnaghan, R. B. A., Vet. Rec., 75, 259 (1963).

    CAS  Google Scholar 

  6. de Iough, H., Vles, R. O., and Van Pelt, J. G., Nature, 202, 466 (1964).

    Article  ADS  Google Scholar 

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Authors and Affiliations

  1. Department of Morbid Anatomy,

    W. H. BUTLER

  2. Department of Chemical Pathology, University College Hospital Medical School, London, W.C.1

    JANET I. CLIFFORD

Authors
  1. W. H. BUTLER
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  2. JANET I. CLIFFORD
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BUTLER, W., CLIFFORD, J. Extraction of Aflatoxin from Rat Liver. Nature 206, 1045–1046 (1965). https://doi.org/10.1038/2061045a0

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