Extraction of Aflatoxin from Rat Liver


It has been shown that a single dose of aflatoxin B1 given to a rat will result in acute liver damage1. Histologically the lesion, which is periportal in distribution, develops slowly as compared with either carbon tetrachloride2 or dimethylnitrosamine (DMN)3. Necrosis is first seen at 36–48 h. The liver parenchyma regenerates slowly and is accompanied by a biliary proliferation. After one month the liver still shows the biliary proliferation and also large hyperchromatic parenchymal cells.

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BUTLER, W., CLIFFORD, J. Extraction of Aflatoxin from Rat Liver. Nature 206, 1045–1046 (1965). https://doi.org/10.1038/2061045a0

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