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Hereditary Cataract induced by X-irradiation of Young Rats


IN a previous investigation1 we showed that about 5 per cent of the offspring of 8- and 17-day-old rats which had been subject to 50, 150, 300 and 500 r. of total-body X-irradiation were dwarfs. At weaning the body-weight of the dwarf animals was half that of the controls of corresponding age, but this difference between normal and dwarfed offsprings decreased with age. In the F2 (from the F1 dwarfed generations) almost the same percentage of dwarfed animals was observed, but, in addition, in F3 some offspring were found with bilateral cataract.

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  1. 1

    Léonard, A., Maisin, J. R., and Malfait, L., C.R. Soc. Biol., 158, 391 (1964).

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  2. 2

    Bourne, M. C., and Gruneberg, H., J. Heredity, 30, 131 (1939).

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  3. 3

    Smith, S. E., and Barrentine, B. F., J. Heredity, 34, 8 (1943).

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LÉONARD, A., MAISIN, J. Hereditary Cataract induced by X-irradiation of Young Rats. Nature 205, 615–616 (1965).

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