Abstract
Crossland, Woodruff and Mitchell1 have recently identified the ‘cerebellar excitatory factor’2,3 as ergothioneine. This factor had been found in extracts of the cerebellum from several mammalian species3 and it was said to have a potent excitatory action on the electrical activity of the cerebellum and the cerebral cortex when injected into the carotid blood stream2,3. The authors therefore concluded that this factor may play a significant part in non-cholinergic synaptic transmission, in the cerebellum and other parts of the central nervous system.
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References
Crossland, J., Woodruff, G. N., and Mitchell, J. F., Nature, 203, 1388 (1964).
Crossland, J., and Mitchell, J. F., J. Physiol., 132, 391 (1956).
Crossland, J., Garven, J. D., and Mitchell, J. F., J. Physiol., 148, 20P (1959).
Krnjević, K., and Phillis, J. W., J. Physiol., 165, 274 (1963).
Heath, H., and Toennies, G., Biochem. J., 68, 204 (1958).
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KRNJEVIĆ, K., RANDIĆ, M. & STRAUGHAN, D. Ergothioneine and Central Neurones. Nature 205, 603–604 (1965). https://doi.org/10.1038/205603a0
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DOI: https://doi.org/10.1038/205603a0
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