Abstract
CHARACTERISTIC of all known schemes of esterase catalysis1–5 is the assumption that the reactive form of serine pre-exists in the enzyme molecule before the interaction of enzyme with substrate or inhibitor. This seems to be unlikely, for why this very reactive form is not involved in side-reactions is still very vague. Moreover, the possibility of the preliminary activation of serine aliphatic hydroxyl, by means of such a weak base as imidazole3–5, is not convincing.
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BRESTKIN, A., ROZENGART, E. Cholinesterase Catalysis. Nature 205, 388–389 (1965). https://doi.org/10.1038/205388a0
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DOI: https://doi.org/10.1038/205388a0
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