Abstract
PROPOXATE is the proposed generic name for dl-1-(1-phenyl-ethyl)-5-(propoxy-carbonyl)-imidazole HCl. It is a member of a new series of 1-substituted imidazole-5-carboxylic acid esters (Fig. 1). The prototype of this series, Etimidate (proposed generic name for R7405), is an extremely potent, rapid and short-acting hypnotic agent in a variety of animal species1. Propoxate (R7464) is a potent, polyvalent and safe anaesthetic in cold-blooded vertebrates and is very soluble in fresh and salt water. Compared with ‘Tricaine’ (methanesulphonate of meta-amino-benzoic acid ethylester, MS222) it is about 100 times more potent, the active concentration ranging from 0.5 to 10 p.p.m. and from 50 to 1,000 p.p.m. for R7464 and MS222 respectively.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Godefroi, E. F., Janssen, P. A. J., Van der Eycken, C. A. M., Van Heertum, A. H. M., and Niemegeers, C. J. E., J. Med. Chem., in the press.
Vaills, L., personal communication.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
THIENPONT, D., NIEMEGEERS, C. Propoxate (R7464) : a New Potent Anaesthetic Agent in Cold-blooded Vertebrates. Nature 205, 1018–1019 (1965). https://doi.org/10.1038/2051018a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/2051018a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
