Abstract
DURING an investigation of the known antidepressant imipramine (‘Tofranil’), this drug was not found to inhibit amino-oxidase, which indicated that this enzyme is not a pre-requisite for antidepressant action1,2. The possibility has been raised that imipramine exerts its antidepressive effect by sensitization of a central nervous adrenergic mechanism3. Later experiments have shown that among a variety of drugs imipramine markedly reduced in vivo concentration of administered tritiated noradrenaline in the heart, spleen and adrenal gland, and concomitantly elevated the plasma level of administered tritiated noradrenaline for the first 5 min. These two facts probably reflected the inhibition of the uptake of catecholamine by tissue caused by imipramine4.
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VÍTEK, V., MOSINGER, B. & KUJALOVÁ, V. In vitro Interference of Antidepressants with Lipolytic Action of Adrenaline on Adipose Tissue. Nature 205, 90–91 (1965). https://doi.org/10.1038/205090b0
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DOI: https://doi.org/10.1038/205090b0
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