Letter | Published:

Brain Tumours induced in Hamsters inoculated intracerebrally at Birth with Rous Sarcoma Virus



IT has been previously shown that new-born hamsters are susceptible to the oncogenic effect of polyoma virus1 introduced intracerebrally2. Likewise, S V 40 virus3 which was shown to be oncogenic when injected subcutaneously into new-born hamsters4 also proved capable of inducing papillary ependymomas after intracerebral inoculation into the same animals5. In recent years a variant of the chicken Rous sarcoma virus (RSV), the Schmidt-Ruppin strain6, has been shown to be oncogenic in a variety of subcutaneously inoculated rodents, including hamsters7. The investigation described here was undertaken to determine the effects of intracerebral inoculation of this virus into new-born hamsters.

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  1. 1

    Stewart, S. E., Eddy, B. E., and Borgese, N. G., J. Nat. Cancer Inst., 20, 1223 (1958).

  2. 2

    Rabson, A. S., and Kierschstein, R. L., Arch. Path., 69, 663 (1960).

  3. 3

    Sweet, B. H., and Hilleman, M. R., Proc. Soc. Exp. Biol. and Med., 105, 420 (1960).

  4. 4

    Eddy, B. E., Borman, G. S., Grubbs, G. E., and Young, R. D., Virology, 17, 65 (1962).

  5. 5

    Kirschstein, R. L., and Gerber, P., Nature, 195, 299 (1962).

  6. 6

    Schmidt-Ruppin, K. H., Sonderbände zur Strahlentherapie, 41, 3, 26 (1959).

  7. 7

    Ahlstrom, C. G., and Forsby, N., J. Exp. Med., 115, 839 (1962).

  8. 8

    Moloney, J. B., J. Nat. Cancer Inst., 16, 877 (1956).

  9. 9

    Zimmerman, H. M., Netsky, M. G., and Davidoff, L. M., Atlas of Tumors of the Nervous System (Lea and Febiger, Philadelphia, 1956).

  10. 10

    Basquez-Lopez, E., Amer. J. Cancer, 26, 29 (1936).

  11. 11

    Vigier, P., Bull. Assoc. pour l'étude du Cancer, 44, 409 (1957).

  12. 12

    Spencer, H. J., and Groupé, V., J. Nat. Cancer Inst., 29, 397 (1962).

  13. 13

    Stewart, H. L., in Physiopathology of Cancer, edit. by Homburger, F., and Fishman, W. H., 84 (P. B. Hoeber, New York, 1953).

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