Letter | Published:

Cell-bound and Cell-binding Antibody in the Peripheral Blood of Immunized Rabbits

Nature volume 204, pages 794795 (21 November 1964) | Download Citation



IN a previous communication we reported on the production of antibody by peripheral blood leucocytes of rabbits1. The following work was undertaken to examine the relationship between cell-bound and cell-binding antibody in blood. The term ‘cell-bound antibody’ is used here to describe substances which at the time of testing were associated with blood leucocytes and enabled these cells to react specifically with the homologous antigen. The expressions ‘cell-binding antibody’ and ‘cytophilic antibody’ will connote globulin components of immune serum which become attached in vitro to cells in such a way that these cells are afterwards capable of specifically absorbing antigen2,3.

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  1. 1.

    , and , Nature, 198, 299 (1963).

  2. 2.

    , in Cell-bound Antibodies, edit. by Amos, B., and Koprowski, H., 7 (Wistar Institute Press, Philadelphia, 1963).

  3. 3.

    , Ciba Foundation Study Group on The Nature and Origin of the Immunologically Competent Cell, (J. and A. Churchill, London, 1963).

  4. 4.

    , and , Immunology, 3, 272 (1960).

  5. 5.

    , and , Immunology, 4, 244 (1961).

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  1. Schweizerisches Forschungsinstitut, Medizinische Abteilung, Davos, Switzerland.



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