Abstract
IT has been found that administration of an adequate dose of d,1-α-tocopheryl acetate (d,1-ATA, 1 mg or more) to vitamin E-deficient rats, not later than the 8th day of gestation, prevented fœtal resorption and insured birth of the usual number of full-term normal young1. When female rats were given vitamin E at too late a stage of pregnancy (after the 12th day of gestation) their fœtuses were partially or wholly resorbed or were dwarfed and dead. Congenital abnormalities occurred when a single dose of 1 mg or more of vitamin E was given at a critical time during gestation, between the 8th and 12th days. Such abnormalities included exencephalus, cleft palate, facial fissures, arrested development of the parietal and occipital bones, nasal fossæ and sternebræ, ectocardia and gastroschisis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cheng, D. W., and Thomas, B. H., Proc. Iowa Acad. Sci., 60, 290 (1953).
Cheng, D. W., Chang, L. F., and Bairnson, T. A., Anat. Rec., 129, 167 (1957).
Cheng, D. W., and Scranton, J., ibid., 133, 367 (1959).
Cheng, D. W., Endocrinol., 64, 270 (1959).
Cheng, D. W., Bairnson, T. A., Rao, A. O., and Subbammal, S., J. Nutrition, 71, 54 (1960).
Cheng, D. W., Braun, K. G., Braun, B. J., and Udani, K. H., ibid., 74, 111 (1961).
Friedman, L., Weiss, W., Wherry, F., and Kline, O. L., ibid., 65, 143 (1958).
Bunnell, R. H., Matterson, L. D., Sigsen, E. P., Potter, L. M., Kozeff, A., and Jungherr, E. L., Poultry Sci., 34, 1068 (1955).
Scott, M. L., Hill, F. W., Norris, L. C., and Dobson, D. C., J. Nutrition, 56, 387 (1955).
Dju, M. Y., Quaife, M. L., and Harris, P. L., Amer. J. Physiol., 160, 259 (1950).
Selzer, G., Parker, R. G. F., McKenzie, D., and Linder, G. C., Brit. J. Exp. Pathol., 32, 493 (1951).
Emerson, G. A., and Dooley, C. L., Fed. Proc., 14, 431 (1955).
Griffiths, T. W., Brit. J. Nutrition, 14, 269 (1960).
Joffe, M., and Harris, P. L., J. Amer. Chem. Soc., 65, 925 (1943).
Harris, P. L., and Ludwig, M. I., J. Biol. Chem., 180, 611 (1949).
Brown, F., Biochem. J., 51, 237 (1952).
Bolliger, H. R., and Bolliger-Quaife, M. L., Rep. Third Intern. Congr. Vitamin E., 30 (1955).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KING, D. Effect of d-Gamma-tocopherol on the Incidence of Teratogeny in Vitamin E-deficient Rats. Nature 204, 785–786 (1964). https://doi.org/10.1038/204785a0
Issue Date:
DOI: https://doi.org/10.1038/204785a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
