Letter | Published:

Patterns of Interferon Appearance in Mice injected with Bacteria or Bacterial Endotoxin

Naturevolume 204page712 (1964) | Download Citation



PREVIOUS work1 has shown that the intravenous injection of large numbers of live Brucella abortus into chickens results in the appearance in the serum of a viral inhibitor with the properties of interferon. Inhibitor reached maximum levels about 12 h after inoculation. It was also reported that large numbers of Newcastle disease virus (NDV) particles produced maximum levels of interferon in chickens about 12 h after intravenous inoculation. Injection of large doses of other gram-positive and -negative bacteria or bacterial endotoxins failed to produce demonstrable inhibitors in the circulation of chickens at 6–8 h.

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    Gledhill, A. W., in Bacterial Endotoxins, edit. by Landy, M., and Braun, W., 410 (Institute of Microbiology, Rutgers, The State University, New Brunswick, N. J., 1964).

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  1. Department of Microbiology, University of Pittsburgh, School of Medicine, Pittsburgh



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