Letter | Published:

Reversal of Hormonal Effects as a Result of Chronic Morphinization

Nature volume 204, page 698 (14 November 1964) | Download Citation



MORPHINE accelerates the rate at which the rat diaphragm takes up glucose from synthetic media, to an extent comparable with the effect of insulin. With tissue from a chronically morphinized animal this acute effect of the drug is reversed, and the rate of glucose-uptake is retarded1. These effects of morphine are antagonized by hydrocortisone2. Hydrocortisone alone, in the concentration used for the experiments (7.7 × 10−4 M) with morphine, has no significant effect on the rate of glucose-uptake by either normal or chronically morphinized tissue. We have confirmed this by additional experiments, and have concluded that the previously observed effects of the hormone in the presence of added morphine may be attributed entirely to a suppression by the hormone of the effects of the drug.

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  1. Department of Biochemistry, University of Hong Kong.

    • E. O'F. WALSH
    • , C. H. LEE PENG
    •  & M. L. NG


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